Your Labs Look Fine.
But Something's
Still Off.
Organic acids testing looks deeper than standard bloodwork — measuring the metabolic byproducts your cells actually produce. It reveals functional deficiencies in energy production, neurotransmitter metabolism, B-vitamin status, and gut health that a normal CBC or CMP will never surface.
The Gap Standard Labs Miss
Normal bloodwork
doesn't mean
optimal function.
Standard serum tests measure what's circulating in your blood. They can't see what's happening inside cells — whether your mitochondria are producing energy efficiently, whether your B-vitamins are actually working at the enzymatic level, or whether gut dysbiosis is producing toxic metabolites that are disrupting your biochemistry.
Organic acids are the metabolic byproducts of these cellular processes. Measuring them in urine gives a functional window into what's actually happening — not just what's present in blood.
What's in your blood
Measures circulating nutrient levels at a snapshot in time. A value in the "normal" range does not confirm that the nutrient is being used efficiently at the cellular level.
What your cells are doing with it
Measures the downstream metabolites produced by cellular processes — revealing enzymatic bottlenecks, functional deficiencies, and metabolic dysfunction that serum levels cannot detect, even when blood values appear normal.
Six Metabolic Pillars
What the test assesses
Each category reflects a distinct functional area — all measured from a single first-morning urine sample collected at home.
Cellular Energy & Mitochondria
Biomarkers of the Krebs cycle and fatty acid oxidation — reveals whether your cells are producing ATP efficiently or experiencing metabolic blockades.
Neurotransmitter Metabolites
Downstream byproducts of serotonin, dopamine, epinephrine, and norepinephrine — shows whether neurotransmitter pathways are functioning or depleted.
B-Vitamin Function
Organic acid markers that depend on specific B-vitamins for enzymatic metabolism — identifies functional insufficiency even when serum B-vitamin levels appear normal.
Gut Dysbiosis Markers
Metabolites produced by bacterial and yeast overgrowth in the gut — detects dysbiosis that may not appear on standard stool testing and can explain systemic symptoms.
Oxidative Stress
Urine markers of free radical damage to lipids and DNA — measures how much oxidative stress your cells are under and whether antioxidant defenses are adequate.
Toxin & Detox Capacity
Markers related to toxic metabolite load and the body's ability to neutralize and clear them — shows whether detox pathways are keeping pace with exposure.
Why This Test Exists
The gap between
"normal" and optimal
is where symptoms live.
Functional deficiencies — where a nutrient is present in circulation but not working properly at the enzymatic level — are common and almost entirely invisible to standard lab testing. Organic acids reveal these bottlenecks directly, without guesswork or elimination diets.
Organic acid markers measured from a single first-morning urine sample
First-morning urine collection — no clinic visit, no blood draw required
Functional imbalance scores reported — methylation, mitochondrial function, oxidative stress, toxic exposure, and more
Who Benefits
Symptoms that don't
add up — even when
labs look normal.
Organic acids testing is most valuable when symptoms are real but standard testing is unrevealing — a pattern clinicians see frequently in patients who've been told everything looks fine.
Associated Conditions & Symptoms
Abnormal organic acid levels are associated with all of the following
The Process
Wake up. Collect. Ship.
Order & Receive
Your Mend practitioner orders the kit — shipped directly to your home. Everything needed for collection is included with prepaid return materials.
Telehealth eligible — all AZFirst-Morning Collection
Collect a first-morning void urine sample before eating or drinking. Simple, non-invasive, and completed entirely at home. Ship the same morning with the prepaid label.
No blood draw requiredPractitioner Review
Results in approximately 14 days. Your practitioner reviews your six functional imbalance scores and builds a targeted nutritional and lifestyle protocol around your specific deficiencies.
Personalized supplement plan includedFAQ
Common Questions
Find out what your
cells are actually doing.
One morning urine sample. Six functional imbalance scores. A personalized protocol targeting the exact nutritional deficiencies your biochemistry reveals.
Important Information
Organic acids testing is a functional assessment tool — not a diagnostic test for disease. Results must be interpreted by a licensed healthcare provider in the context of your full clinical history and symptoms. Elevated or abnormal organic acid markers indicate areas of potential metabolic dysfunction; they do not diagnose specific conditions. This test is not intended for the diagnosis of neonatal inborn errors of metabolism and is not suitable for patients under 2 years of age.
Testing is performed at a CLIA-certified laboratory. Results are typically available 14 business days after lab receipt of samples. Certain supplements and medications may affect test results — consult your practitioner before collection. Insurance coverage varies; this is typically a self-pay service. HSA/FSA eligibility applies for practitioner-ordered diagnostic tests. Mend Medical is not affiliated with Genova Diagnostics.