Advanced gut health diagnostics laboratory
Advanced Diagnostics · Gut Health

Your Gut Drives
More Than You
Think.

The GI Effects® Comprehensive Stool Analysis evaluates digestion, gut inflammation, and your complete microbiome from a single at-home sample — giving your practitioner the data to address what standard labs miss entirely.

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HSA / FSAEligible
70%
Of your immune system lives in your gut
90%
Of serotonin is produced in the gut — not the brain
38T
Microbial cells in the human gut — roughly equal to human cells
1,000+
Peer-reviewed studies linking gut dysbiosis to chronic disease

The Problem

An imbalanced gut
affects everything
outside it.

Research now links a dysbiotic microbiome — too many harmful organisms, too few beneficial ones — to conditions far beyond digestion.

Standard labs don't evaluate the gut. The GI Effects panel does what a routine blood panel cannot: it shows whether your gut is digesting properly, whether inflammation is present, and whether your microbiome is balanced, overgrown, or missing key organisms.

Immune Function
Gut dysbiosis drives chronic inflammation and immune dysregulation
Brain & Mood
The gut-brain axis links microbiome health to anxiety, depression, and cognition
Metabolism & Weight
Microbiome composition influences insulin sensitivity, appetite, and fat storage
Hormones
The "estrobolome" — gut bacteria — directly regulates estrogen reabsorption and clearance
Cardiovascular Health
Gut-produced metabolites like TMAO are directly linked to atherosclerosis risk

What Gets Tested

Three pillars of gut health — assessed simultaneously

The GI Effects uses the DIG framework — Digestion, Inflammation, and the Gut microbiome — to give a complete clinical picture from one sample.

Digestion & Absorption

Is your gut actually breaking down food and absorbing nutrients — or is undigested matter feeding the wrong organisms?

Pancreatic Elastase-1
Marker of exocrine pancreatic enzyme output — low levels indicate enzyme insufficiency
Fecal Fat
Indicates how well dietary fat is being broken down and absorbed
Products of Protein Breakdown
Undigested protein reaching the colon — a fuel source for harmful bacteria

Inflammation & Immunity

Is your gut wall intact, or is immune activation quietly driving systemic inflammation throughout the body?

Calprotectin
Key inflammatory marker — clinically validated to differentiate IBS from IBD
Secretory IgA
Primary gut immune defense — reflects barrier integrity and mucosal immunity
Eosinophil Protein X
Marker of allergic-type gut inflammation and eosinophil activity
Fecal Occult Blood
ACG-recommended colorectal cancer screening using immunochemical testing

Gut Microbiome

What organisms are living in your gut — and are the beneficial ones winning, losing, or absent entirely?

24 Commensal Bacteria (qPCR)
Composition and abundance across 7 major phyla — including anaerobes standard culture misses
Dysbiosis Score
Genova's proprietary inflammation-associated and methane dysbiosis scoring
Short-Chain Fatty Acids
Butyrate and other SCFAs — essential metabolites that protect the gut lining
Parasitology (PCR + Microscopy)
6 PCR targets + gold-standard microscopic O&P exam for Giardia, Blastocystis, and others
Optional Add-On

Go deeper with
Microbiomix™

The GI Effects gives you a comprehensive gut snapshot. Microbiomix layers in whole-genome metagenomic sequencing — the gold standard method for microbiome analysis — detecting over 28,000 species and the metabolites they're producing.

Add it to your GI Effects order for the most complete gut health assessment available anywhere.

Ask About Microbiomix

Also available as a stand-alone test

28K+
Species detected
Bacteria, fungi, protists, and archaea — including newly discovered species not in public databases
200+
Species per person
Your complete microbiome listed in a personalized report — with Shannon Diversity scoring
WGS
Whole genome sequencing
Assesses metabolite potential: GABA, histamine, TMAO, vitamin production, hydrogen sulfide, and more
Lifetime report updates
As science advances, your report is updated — the most clinically forward approach in the industry

Clinical Context

The gut shows up
in places you
wouldn't expect.

Research associates gut dysbiosis with conditions both inside and outside the GI tract — many of which don't appear gut-related on the surface.

Associated Conditions

GI Effects provides clinical data relevant to all of the following

IBSIBD / Crohn'sBloating & GasConstipationDiarrheaGERD / RefluxLeaky GutSIBODepression & AnxietyBrain FogAutoimmune DiseaseEczema / Atopic DermatitisFood SensitivitiesAllergiesType 2 DiabetesInsulin ResistanceObesityHormone ImbalanceJoint PainCardiovascular RiskNutrient DeficienciesChronic Fatigue

The Process

At-home. Simple. Actionable.

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Order & Receive

Your Mend practitioner orders the kit — shipped directly to your door with everything included and a prepaid return label.

Telehealth eligible — all AZ

Collect at Home

Simple stool collection using the materials provided. No dietary restrictions required for most markers. Ship the same day with the prepaid FedEx label.

1-day or 3-day collection options

Practitioner Review

Results in approximately 14 days from Genova's CLIA-certified lab. Your practitioner reviews all three pillars and builds a personalized protocol around the findings.

Targeted, data-driven protocol

FAQ

Common Questions

Your gut affects
everything. Know its status.

One at-home collection. Three clinical pillars assessed. A practitioner-built protocol that addresses the root — not the symptom.

Book Now
HSA / FSAEligible
At-Home Collection
CLIA-Certified Lab
Telehealth Eligible — All AZ
Microbiomix Add-On Available

Important Information

The GI Effects® Comprehensive Stool Profile is a clinical assessment tool — not a diagnostic test for disease. Results must be interpreted by a licensed healthcare provider in the context of your full clinical history and symptoms. This test does not diagnose inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, or any other condition. Abnormal results indicate areas warranting further clinical evaluation.

GI Effects® and Microbiomix™ are products of Genova Diagnostics, Inc. — a CLIA-certified and CAP-accredited laboratory. Mend Medical is not affiliated with Genova Diagnostics. Testing is ordered by a licensed practitioner. Insurance coverage varies; HSA/FSA eligibility applies for practitioner-ordered diagnostic tests. Some products not available in New York. Allow 14 business days for results after lab receipt of samples. Do not collect during an acute gastrointestinal illness.